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Figure 8 | PathoGenetics

Figure 8

From: Mutations in the nuclear localization sequence of the Aristaless related homeobox; sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division

Figure 8

Increased proportion of mitotic cells transfected with nuclear localization sequence (NLS) mutant ARX. (A) The percentage of HEK293T cells transfected and (B) the percentage of mitotic cells transfected with Myc-ARX-Wt or NLS mutant constructs for 24, 48 and 72 h was determined from between 1200 and 4000 cells per sample, from at least three separate transfection reactions. Full-length Myc-tagged constructs transfected are indicated in the legend ARX Wt (open), R332P (vertical light grey stripes), T333N (grey), R379L (horizontal dark grey) and R379S (dark grey) with the time post-transfection indicated on the X-axis.

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