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Figure 6 | PathoGenetics

Figure 6

From: Mutations in the nuclear localization sequence of the Aristaless related homeobox; sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division

Figure 6

Mitotic spindles disrupted by aggregates of NLS mutant ARX protein. A representative pictomicrograph of a HEK293T cell transfected with mutant Myc-ARX undergoing DNA condensation stage of mitosis shows abnormal pattern of DNA condensation (DAPI) microtubule formation (alpha-tubulin) around a large aggregate of mutant ARX protein (Myc-ARX) with the remaining Myc-ARX signal localized diffusely throughout the cell interior. Scale bar = 10 μM.

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