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Table 2 Gene expression fold-change differences in islets from BLKS mice compared with those from B6 mice

From: Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

    Interstrain fold difference (BLKS/B6)    
Probe Gene Description Low Gluc. High Gluc. Chromosome Mb Genetic Origin
A_51_P417251 6330403K07RIK RIKEN cDNA 4.32 17.43 11 71.1 DBA
A_52_P532456 PLAGL1 pleiomorphic adenoma gene-like 1 2.93 7.15 10 12.8 DBA
A_51_P113395 NNT nicotinamide nucleotide transhydrogenase 1.94 4.22 13 116.6 DBA
A_52_P395228 NNT nicotinamide nucleotide transhydrogenase 2.01 4.07 13 116.6 DBA
A_51_P113399 NNT nicotinamide nucleotide transhydrogenase 1.79 3.85 13 116.6 DBA
A_51_P422030 FLJ22709 hypothetical protein 1.99 3.82 8 69.8 DBA
A_51_P358765 SPP1 secreted phosphoprotein 1 2.46 3.76 5 103.6 B6
A_51_P253984 PCP4 Purkinje cell protein 4 1.93 3.52 16 96.9 DBA
A_51_P402943 S100A9 S100 calcium-binding protein A9 1.21 3.28 3 90.8 DBA
A_52_P542860 BTBD9 BTB domain-containing 9 1.99 3.27 17 28.7 DBA
A_51_P440682 CAP1 CAP, adenylate cyclase-associated protein 1 1.82 3.17 4 122.3 DBA
A_52_P3029 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 1.42 2.92 17 10.9 DBA
A_51_P323620 THYN1 thymocyte nuclear protein 1 1.74 2.91 9 26.9 other
A_51_P346165 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 1.42 2.89 17 10.9 DBA
A_51_P118417 SCPEP1 serine carboxypeptidase 1 1.70 2.87 11 89.0 DBA
A_51_P454873 NPY neuropeptide Y 1.97 2.72 6 49.8 B6
A_51_P491017 GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 1.82 2.71 17 23.4 DBA
A_52_P748882 ENO2 enolase 2 1.62 2.58 6 124.8 DBA
A_51_P167535 FABP3 fatty acid-binding protein 3 1.88 2.53 4 129.8 DBA?
A_51_P130028 ENO2 enolase 2 1.63 2.53 6 124.8 DBA
A_51_P101545 HGFAC HGF activator -1.92 -2.54 5 34.1 DBA
A_51_P337269 ALDOB aldolase B, fructose-bisphosphate -1.17 -2.66 4 49.6 B6
A_51_P215627 PLAC9 placenta-specific 9 -1.89 -2.67 14 23.6 DBA
A_52_P644774 ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -1.92 -2.73 11 73.0 DBA
A_51_P517075 SERPINF1 serpin peptidase inhibitor, clade F member 1 -1.50 -2.78 11 75.5 DBA
A_52_P213889 TMC7 transmembrane channel-like 7 -1.87 -2.83 7 114.5 DBA
A_52_P613498 4833420G17RIK RIKEN cDNA -2.04 -3.01 13 116.7 DBA
A_51_P376656 SYNPR synaptoporin -2.13 -3.08 14 11.4 DBA
A_52_P50496 HLA-A major histocompatibility complex, class I, A -2.23 -3.16 17 32.1 DBA
A_51_P509961 SLC5A10 solute carrier family 5 member 10 -1.21 -3.24 11 61.8 DBA
A_51_P246677 REC8L1 REC8-like 1 -2.28 -3.61 14 50.5 DBA
A_51_P392518 THUMPD1 THUMP domain-containing 1 -2.83 -4.30 7 115.6 DBA
A_51_P146560 MSLN mesothelin -2.31 -4.36 17 23.9 DBA
A_52_P137500 AK046255 Unknown cDNA -2.70 -5.06 X 131.8 DBA
A_51_P443443 5830417I10RIK RIKEN cDNA -2.75 -5.46 3 89.0 DBA
A_52_P231729 H2-Q1 major histocompatibility complex Q1b -8.74 -29.31 17 33.4 DBA
  1. Shown is the subset with fold change >2.5 under high glucose conditions (p < 0.001, Benjamini-Hochberg FDR 0.8). Genes are sorted by the interstrain fold difference in high glucose conditions.
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PathoGenetics

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