Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

Anderson, Abraham A; Helmering, Joan; Juan, Todd; Li, Chi-Ming; McCormick, Jocelyn; Graham, Melissa; Baker, Daniel M; Damore, Michael A; Véniant, Murielle M; Lloyd, David J

doi:10.1186/1755-8417-2-1

Table 1 Gene expression fold-change differences in islets from low to high glucose in BLKS and B6 mice

From: Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

Probe	Gene	Description	Interstrain fold difference (BLKS/B6)		Glucose response (fold change)
			Low Gluc.	High Gluc.	B6	BLKS
A_51_P402943	S100A9	S100 calcium-binding protein A9	1.21	3.28	1.59	4.31
A_51_P438805	TXNIP	thioredoxin-interacting protein	-1.72	-2.01	4.16	3.56
A_51_P358765	SPP1	secreted phosphoprotein 1	2.46	3.76	2.12	3.24
A_51_P275016	SLC7A3	solute carrier family 7 member 3	1.49	1.97	2.13	2.82
A_51_P372550	CGREF1	cell growth regulator with EF-hand domain 1	1.04	1.65	1.76	2.79
A_51_P510156	LCN2	lipocalin 2	1.98	2.07	2.31	2.41
A_52_P94482	TTYH1	tweety homolog 1	1.73	1.84	2.23	2.37
A_51_P194149	TTR	transthyretin	-1.31	1.13	1.59	2.37
A_51_P428384	TTYH1	tweety homolog 1	1.58	2.19	1.70	2.36
A_52_P326399	FKBP11	FK506-binding protein 11	1.50	1.48	2.39	2.36
A_51_P130727	FKBP11	FK506-binding protein 11	1.65	1.64	2.34	2.33
A_51_P227275	CSN3	casein kappa	1.43	1.54	2.15	2.31
A_51_P370458	A030006P16RIK	RIKEN cDNA	1.01	1.64	1.41	2.29
A_51_P391955	2310032F03RIK	RIKEN cDNA	1.10	1.21	2.07	2.27
A_51_P346938	LRG1	leucine-rich alpha-2-glycoprotein 1	1.18	1.17	2.22	2.20
A_52_P187058	NPTX2	neuronal pentraxin II	1.67	2.38	1.51	2.16
A_51_P435911	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	1.17	1.69	1.46	2.11
A_51_P162955	SERPINA7	serpin peptidase inhibitor member 7	-1.01	1.21	1.69	2.07
A_52_P547328	TRAM1	translocation-associated membrane protein 1	1.09	1.51	1.49	2.06
A_51_P272876	FAM46A	family with sequence similarity 46, member A	1.59	1.72	1.88	2.03
A_52_P144310	GAD1	glutamate decarboxylase 1	1.02	-1.23	-1.63	-2.04
A_51_P199352	2310015B20RIK	RIKEN cDNA	-1.25	-1.71	-1.62	-2.21

Genes are sorted for the subset with BLKS glucose response (fold change) >2 (p < 0.001, Benjamini-Hochberg FDR 0.8).

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