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Figure 3 | PathoGenetics

Figure 3

From: Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

Figure 3

Plagl1 expression and genetic differences in BLKS mice. (A) Quantitative RT-PCR analysis of the Plagl1t RNA in B6 and BLKS in isolated islet cultured in high glucose conditions. Data represent means and standard deviations of multiple mice (B6 n = 8; BLKS n = 4) and tested using a two-tailed Student's T-test assuming unequal variances; *** P < 0.001. (B) Diagram of the polypeptide structure of Plagl1 identifying the functional domains. Numbers refer to the mouse amino-acid positions, and letters refer to amino acids. The genetic differences between B6 and BLKS genes are shown by the stars; the two-amino acid deletion in BLKS is shown by the arrow.

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PathoGenetics

ISSN: 1755-8417