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Figure 3 | PathoGenetics

Figure 3

From: Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts

Figure 3

Pompe disease fibroblasts show abnormal distribution of Golgi and trans-Golgi network markers. Immunofluorescence analysis of markers of the Golgi apparatus. The cells were visualized by confocal fluorescence microscopy. Insets show high magnification views. The merged image of double staining is shown. The cells were fixed, permeabilized and stained with anti-Mannosidase II (green), anti-GM130 (red) (A), and with anti-Golgin 97 (green) (B). All markers showed abnormal distribution and expansion of the Golgi apparatus in intermediate and severe Pompe disease fibroblasts.

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