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Figure 1 | PathoGenetics

Figure 1

From: Transfection of the mutant MYH9 cDNA reproduces the most typical cellular phenotype of MYH9-related disease in different cell lines

Figure 1

Transfection of D1424H MYH9 in COS-7 or HeLa cells results in the formation of NMMHC-IIA aggregates similar to those of granulocytes of MYH9 -RD patients carrying the same mutation. A) COS-7 cells transfected with WT MYH9 cDNA. B) COS-7 cells transfected with D1424H MYH9 cDNA. C) HeLa cells transfected with D1424H MYH9 cDNA. D) Staining of granulocyte from an unaffected individual. E) and F) Staining of granulocytes from patients with the D1424H substitution obtained by labeling the peripheral blood smears for NMMHC-IIA. Scale bars correspond to 10 μm. Arrows indicate rod-like aggregates.

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PathoGenetics

ISSN: 1755-8417