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Figure 6 | PathoGenetics

Figure 6

From: Mechanisms for human genomic rearrangements

Figure 6

Genomic architecture is crucial for the genomic rearrangements. The low-copy repeats serve as substrates and thus are an indispensable requirement of non-allelic homologous recombination. Current data suggest that local genomic architecture, including palindromes or cruciforms, might be a stimulus for the Fork Stalling and Template Switching (FoSTeS) rearrangement as well, although these architectural elements are not necessarily directly involved in the FoSTeS rearrangement per se. This could account for the observation of breakpoint grouping with non-recurrent rearrangements at some loci.

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